MUTAGENIC ACTIVITY OF EPOXY EMBEDDING REAGENTS EMPLOYED IN ELECTRON-MICROSCOPY

被引：14
作者：
MURRAY, MP
CUMMINS, JE
机构：
[1] Department of Plant Sciences, University of Western Ontario, London, Ontario
来源：
ENVIRONMENTAL MUTAGENESIS | 1979年 / 1卷 / 04期
关键词：
aliphatic diepoxides; Ames Salmonella typhimurium system; aromatic epoxy resins; cyclic aliphatic diepoxides; electron microscopy embedding media;
D O I：
10.1002/em.2860010402
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Components of epoxy‐based embedding media used in electron microscopy were examined for their mutagenicity in the Ames Salmonella system. The compounds, singly and in combination, were shown to be active with strain TA100 (base substitution indicator) but not with TA98 (frameshift indicator). When tested separately the epoxy resins Araldite, Epon, and vinyl cyclohexen dioxide (VCD) and the plasticizer diglycidyl ether of propylene glycol (DER‐736) were found to be significantly mutagenic. These active compounds, in combination with liver mixed oxidase preparation (S9), showed increased mutagenicity over similar preparations in the absence of microsomal activation. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
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页码：307 / 313
页数：7
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