REGULATION OF MHC GENE-EXPRESSION

被引：220

作者：

TING, JPY ^{[1
]}

BALDWIN, AS ^{[1
]}

机构：

[1] UNIV N CAROLINA,LINEBERGER COMPREHENS CANC RES CTR,DEPT BIOL,CHAPEL HILL,NC 27599

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 01期

关键词：

D O I：

10.1016/0952-7915(93)90074-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review focuses on recent progress made in MHC regulation. The better characterization of proteins that interact with MHC class I and II promoters and the isolation of genes encoding several of these transcription factors, such as H-2RIIBP/RXRbeta, NKkappaB, I-kappaB, hXBP-1 and NF-Y, allow the functional analysis of these molecules in MHC gene regulation. The application of new techniques, such as genomic in vivo footprinting analysis, to the study of these promoters provides insights into the status of in vivo protein-DNA interaction over these promoters. New insights have also been gained in the understanding of MHC-associated genes.

引用

页码：8 / 16

页数：9

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