BIOLOGICALLY IMPORTANT PHYSICOCHEMICAL PROPERTIES OF KOJIC ACID-DERIVATIVES

被引：16

作者：

BALAZ, S

STURDIK, E

UJHELYOVA, R

VALIGURA, D

UHER, M

VEVERKA, M

KONECNY, V

ADAMCOVA, J

MICHALIK, P

BRTKO, J

机构：

[1] SLOVAK UNIV TECHNOL BRATISLAVA, DEPT INORGAN CHEM, CS-81237 BRATISLAVA, CZECHOSLOVAKIA

[2] SLOVAK UNIV TECHNOL BRATISLAVA, DEPT ORGAN CHEM, CS-81237 BRATISLAVA, CZECHOSLOVAKIA

[3] RES INST CHEM TECHNOL, CS-83106 BRATISLAVA, CZECHOSLOVAKIA

[4] RES INST STARCH IND, CS-82006 BRATISLAVA, CZECHOSLOVAKIA

[5] SLOVAK ACAD SCI, INST ENDOCRINOL, CS-83306 BRATISLAVA, CZECHOSLOVAKIA

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1993年 / 58卷 / 03期

关键词：

D O I：

10.1135/cccc19930693

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Physicochemical properties (hydrophobicity. acidity. metal complexing ability). which are expected to play a role in biological activity of kojic acid derivatives. were determined for 35 compounds. The structure-property relationships were analysed with the aim to predict the properties of new derivatives and to obtain the data for formulation of quantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of the 1-octanol/buffer partition coefficient and the sum of fragment constants and correction factors according to Leo and Hansch as well as between acidity and a set of Hammett constants of the varying substituents.

引用

页码：693 / 701

页数：9

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