INHIBITION OF CALCIUM ENTRY INDUCED BY CULARINES AND ISOCRASIFOLINE IN UTERINE SMOOTH-MUSCLE

被引：42
作者：
DOCON, P
BLASCO, R
CANDENAS, L
IVORRA, D
LOPEZ, S
VILLAVERDE, C
CASTEDO, L
CORTES, D
机构：
[1] UNIV SANTIAGO DE COMPOSTELA, FAC CIENCIAS QUIM, DEPT QUIM ORGAN, SANTIAGO, SPAIN
[2] UNIV ROUEN HAUTE NORMANDIE, FAC MED & PHARM, PHARMACOGNOSIE LAB, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 196卷 / 02期
关键词：
PAPAVERINE; CULARINE; BENZYLISOQUINOLINES; CA2+ CHANNEL ANTAGONISTS; NIFEDIPINE; UTERUS;
D O I：
10.1016/0014-2999(91)90426-Q
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of nifedipine, papaverine and four benzylisoquinoline alkaloids (cularine, cularidine, celtisine and isocrasifoline) were studied in isolated rat uterus in order to clarify the mechanism of their relaxant action. All the compounds tested completely relaxed KCl-induced contractions and totally or partially inhibited oxytocin-induced rhythmic contractions. Only papaverine acted intracellularly, promoting relaxation of contractile responses induced by oxytocin or vanadate in a Ca2+-free medium. In spite of the structural relationship between papaverine and the other alkaloids, the mechanism of their relaxant action is not the same. The activities of cularine derivatives and of isocrasifoline were similar to that of nifedipine.
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页码：183 / 187
页数：5
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