THE METABOLISM OF CGP-291 - THE USE OF MICROORGANISMS AS MODELS OF MAMMALIAN METABOLISM

被引：3
作者：
JURGENS, TM
CLARK, AM
机构：
[1] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677
[2] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677
来源：
PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 07期
关键词：
CGP-291; metabolism; microbial metabolites; niridazole;
D O I：
10.1023/A:1015871723330
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
CGP-291 is an investigational antiprotozoal agent with unknown metabolism. Microbial systems were utilized, as a model of mammalian metabolism, to predict the oxidative metabolic pathway of this nitroimidazole. Large-scale fermentation of CGP-291 with Beauvaria bassiana produced two major metabolites, IV and V. Structures of both were elucidated by comparing spectral data of metabolites to that of the starting material. The presence of two minor monohydroxylated metabolites was verified using LC-MS. © 1990, Plenum Publishing Corporation. All rights reserved.
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页码：742 / 745
页数：4
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