Iron overload-related heart failure in a patient with transfusion-dependent myelodysplastic syndrome reversed by intensive combined chelation therapy

被引：5
作者：
Pinto, Valeria [1 ]
Balocco, Manuela [1 ]
Ambaglio, Ilaria [2 ]
Derchi, Giorgio [3 ]
Malcovati, Luca [2 ]
Forni, Gian Luca [1 ]
机构：
[1] Osped Galliera, Ematol Ctr Microcitemia & Anemie Congenite, Via Volta 6, I-16128 Genoa, Italy
[2] Policlin San Matteo, Fdn Ist Ricovero & Cura Carattere Sci IRCCS, Dept Hematol Oncol, I-27100 Pavia, Italy
[3] Osped Galliera, Unit Cardiol, Genoa, Italy
来源：
CLINICAL CASE REPORTS | 2015年 / 3卷 / 11期
关键词：
Deferiprone; desferal; heart failure; iron chelation; myelodysplastic syndromes;
D O I：
10.1002/ccr3.407
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Key Clinical Message Patients with transfusion-dependent myelodysplastic syndromes (MDS) have an increased risk of cardiac events, due to both chronic anemia and iron overload. Here, we report the recovery of cardiac function after an intensive iron chelation therapy in a MDS patient who had developed heart failure due to iron overload.
引用
收藏
页码：952 / 954
页数：3
相关论文
共 11 条
  • [1] Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1
    Ambaglio, Ilaria
    Malcovati, Luca
    Papaemmanuil, Elli
    Laarakkers, Coby M.
    Della Porta, Matteo G.
    Galli, Anna
    Da Via, Matteo C.
    Bono, Elisa
    Ubezio, Marta
    Travaglino, Erica
    Albertini, Riccardo
    Campbell, Peter J.
    Swinkels, Dorine W.
    Cazzola, Mario
    [J]. HAEMATOLOGICA, 2013, 98 (03) : 420 - 423
  • [2] Borgna-Pignatti C, 2004, HAEMATOLOGICA, V89, P1187
  • [3] EFFICACY AND SAFETY OF ADMINISTRATION OF ORAL IRON CHELATOR DEFERIPRONE IN PATIENTS WITH EARLY MYELODYSPLASTIC SYNDROME
    Cermak, Jaroslav
    Jonasova, Anna
    Vondrakova, Jana
    Walterova, Lenka
    Hochova, Ivana
    Siskova, Magda
    Neuwirtova, Radana
    [J]. HEMOGLOBIN, 2011, 35 (03) : 217 - 227
  • [4] How I treat transfusional iron overload
    Hoffbrand, A. Victor
    Taher, Ali
    Cappellini, Maria Domenica
    [J]. BLOOD, 2012, 120 (18) : 3657 - 3669
  • [5] Increased survival and reversion of iron-induced cardiac disease in patients with thalassemia major receiving intensive combined chelation therapy as compared to desferoxamine alone
    Lai, Maria Eliana
    Grady, Robert W.
    Vacquer, Stefania
    Pepe, Alessia
    Carta, Maria Paola
    Bina, Patrizio
    Sau, Franco
    Cianciulli, Paolo
    Maggio, Aurelio
    Galanello, Renzo
    Farci, Patrizia
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2010, 45 (02) : 136 - 139
  • [6] SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
    Malcovati, Luca
    Karimi, Mohsen
    Papaemmanuil, Elli
    Ambaglio, Ilaria
    Jadersten, Martin
    Jansson, Monika
    Elena, Chiara
    Galli, Anna
    Walldin, Gunilla
    Della Porta, Matteo G.
    Raaschou-Jensen, Klas
    Travaglino, Erica
    Kallenbach, Klaus
    Pietra, Daniela
    Ljungstrom, Viktor
    Conte, Simona
    Boveri, Emanuela
    Invernizzi, Rosangela
    Rosenquist, Richard
    Campbell, Peter J.
    Cazzola, Mario
    Lindberg, Eva Hellstrom
    [J]. BLOOD, 2015, 126 (02) : 233 - 241
  • [7] Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia
    Malcovati, Luca
    Papaemmanuil, Elli
    Ambaglio, Ilaria
    Elena, Chiara
    Galli, Anna
    Della Porta, Matteo G.
    Travaglino, Erica
    Pietra, Daniela
    Pascutto, Cristiana
    Ubezio, Marta
    Bono, Elisa
    Da Via, Matteo C.
    Brisci, Angela
    Bruno, Francesca
    Cremonesi, Laura
    Ferrari, Maurizio
    Boveri, Emanuela
    Invernizzi, Rosangela
    Campbell, Peter J.
    Cazzola, Mario
    [J]. BLOOD, 2014, 124 (09) : 1513 - 1521
  • [8] Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet
    Malcovati, Luca
    Hellstrom-Lindberg, Eva
    Bowen, David
    Ades, Lionel
    Cermak, Jaroslav
    del Canizo, Consuelo
    Della Porta, Matteo G.
    Fenaux, Pierre
    Gattermann, Norbert
    Germing, Ulrich
    Jansen, Joop H.
    Mittelman, Moshe
    Mufti, Ghulam
    Platzbecker, Uwe
    Sanz, Guillermo F.
    Selleslag, Dominik
    Skov-Holm, Mette
    Stauder, Reinhard
    Symeonidis, Argiris
    van de Loosdrecht, Arjan A.
    de Witte, Theo
    Cazzola, Mario
    [J]. BLOOD, 2013, 122 (17) : 2943 - 2964
  • [9] Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)
    Malcovati, Luca
    Della Porta, Matteo G.
    Strupp, Corinna
    Ambaglio, Ilaria
    Kuendgen, Andrea
    Nachtkamp, Kathrin
    Travaglino, Erica
    Invernizzi, Rosangela
    Pascutto, Cristiana
    Lazzarino, Mario
    Germing, Ulrich
    Cazzola, Mario
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (10): : 1433 - 1440
  • [10] Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance
    Modell, Bernadette
    Khan, Maren
    Darlison, Matthew
    Westwood, Mark A.
    Ingram, David
    Pennell, Dudley J.
    [J]. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2008, 10 (1)
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