A MATERNALLY-INHERITED ALTERATION IN THE T-CELL REPERTOIRE OF BALB/C MICE

被引:0
作者
GOLDMAN, A
BUGGIANO, V
FRANCO, M
DEROCHE, A
NEPOMNASCHY, I
PIAZZON, I
机构
关键词
MURINE MAMMARY TUMOR VIRUS; T CELL RECEPTOR;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A number of milk-borne exogenous mammary tumor viruses (MMTV) infect mice shortly after birth and, when expressed, produce superantigens. The expression of these superantigens mediate the progressive deletion of T cells expressing specific V beta products. Here we describe a maternally-inherited alteration in the T cell repertoire in one colony of BALB/c mice which has not been reported up to now. This alteration involves the deletion of V beta 2+ and 41+ CD4+ T cells and correlates with a high incidence of mammary tumors, suggesting the involvement of a superantigen(s) probably transmitted through an exogenous MMTV in milk.
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页码:45 / 47
页数:3
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