A MATERNALLY-INHERITED ALTERATION IN THE T-CELL REPERTOIRE OF BALB/C MICE

被引：0
作者：
GOLDMAN, A
BUGGIANO, V
FRANCO, M
DEROCHE, A
NEPOMNASCHY, I
PIAZZON, I
机构：
来源：
MEDICINA-BUENOS AIRES | 1995年 / 55卷 / 01期
关键词：
MURINE MAMMARY TUMOR VIRUS; T CELL RECEPTOR;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A number of milk-borne exogenous mammary tumor viruses (MMTV) infect mice shortly after birth and, when expressed, produce superantigens. The expression of these superantigens mediate the progressive deletion of T cells expressing specific V beta products. Here we describe a maternally-inherited alteration in the T cell repertoire in one colony of BALB/c mice which has not been reported up to now. This alteration involves the deletion of V beta 2+ and 41+ CD4+ T cells and correlates with a high incidence of mammary tumors, suggesting the involvement of a superantigen(s) probably transmitted through an exogenous MMTV in milk.
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页码：45 / 47
页数：3
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