A MATERNALLY-INHERITED ALTERATION IN THE T-CELL REPERTOIRE OF BALB/C MICE

被引：0

作者：

GOLDMAN, A

BUGGIANO, V

FRANCO, M

DEROCHE, A

NEPOMNASCHY, I

PIAZZON, I

机构：

来源：

MEDICINA-BUENOS AIRES | 1995年 / 55卷 / 01期

关键词：

MURINE MAMMARY TUMOR VIRUS; T CELL RECEPTOR;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A number of milk-borne exogenous mammary tumor viruses (MMTV) infect mice shortly after birth and, when expressed, produce superantigens. The expression of these superantigens mediate the progressive deletion of T cells expressing specific V beta products. Here we describe a maternally-inherited alteration in the T cell repertoire in one colony of BALB/c mice which has not been reported up to now. This alteration involves the deletion of V beta 2+ and 41+ CD4+ T cells and correlates with a high incidence of mammary tumors, suggesting the involvement of a superantigen(s) probably transmitted through an exogenous MMTV in milk.

引用

页码：45 / 47

页数：3

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