Three cases of secondary syphilis were seen in the Departments of Obstetrics & Gynaecology, Surgery and Dermatology. One was typical of secondary syphilis with skin manifestations as well as systemic illness, whilst the other two were not typical. One manifested as anal fissure and was diagnosed by dark ground examination as well as serologic tests for syphilis; the other presented as palmar, plantar hyperkeratosis and a scrotal ulceration. The significance of secondary syphilis in different specialities and its diagnosis are discussed.