ON THE MECHANISM OF HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF PATIENTS WITH CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

被引：83

作者：

VANDOORN, PA

ROSSI, F

BRAND, A

VANLINT, M

VERMEULEN, M

KAZATCHKINE, MD

机构：

[1] STATE UNIV LEIDEN HOSP,DEPT IMMUNOHEMATOL & BLOOD BANK,2333 AA LEIDEN,NETHERLANDS

[2] HOP BROUSSAIS,UNITE IMMUNOPATHOL,F-75674 PARIS 14,FRANCE

[3] HOP BROUSSAIS,INSERM,U28,F-75674 PARIS 14,FRANCE

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 29卷 / 1-3期

关键词：

Chronic inflammatory demyelinating polyneuropathy; Guillain-Barré; syndrome; Neuroblastoma cell line; Normal polyspecific immunoglobulin for intravenous use;

D O I：

10.1016/0165-5728(90)90147-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A proportion of patients with a chronic inflammatory demyelinating polyneuropathy (CIDP) improves after polyvalent intravenous immunoglobulin (IVIg) treatment. When anti-neuroblastoma cell line (NBL) antibodies are present, they decrease or disappear after IVIg treatment. Purified IgM anti-NBL antibodies from a CIDP patient were inhibited by F(ab′)2 of IVIg and by F(ab′)2 of a patient recovered from Guillain-Barré syndrome (GBS). Inhibition of anti-NBL antibodies was also found among sera from normal individuals. This suggests that the self-limiting character of GBS and the therapeutic effect of IVIg in CIDP are dependent on suppression of auto-antibodies. This suppression may be mediated by anti-idiotypes present in recovered GBS patients and in the normal donor population contributing to IVIg. © 1990.

引用

页码：57 / 64

页数：8

共 32 条

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