VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS IS CORRELATED WITH THE ABSENCE OF HIGH-AFFINITY AVIDITY MATERNAL ANTIBODIES TO THE GP120 PRINCIPAL NEUTRALIZING DOMAIN

被引：235

作者：

DEVASH, Y

CALVELLI, TA

WOOD, DG

REAGAN, KJ

RUBINSTEIN, A

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,BRONX,NY 10461

[2] DUPONT CO,DEPT MED PROD,GLASGOW,DE 19714

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 09期

关键词：

D O I：

10.1073/pnas.87.9.3445

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many, but not all, infants born to mothers infected with the human immunodeficiency virus (HIV) are infected in utero. We have now shown that mothers who have high-affinity/avidity antibodies directed toward the principal neutralizing domain (PND) of gp120 are less likely to transmit HIV to their children. An ELISA that preferentially measures the level of the biologically functioning, high-affinity/avidity antibodies against PND is described. In a retrospective study of 15 maternal/neonatal serum samples, the assay correctly identified the 4 uninfected and the 11 HIV-infected infants. Other clinical and laboratory parameters such as p24 antigen, phytohemagglutinin mitogenic index, and absolute surface antigen T4+ cell counts did not accurately predict HIV fetal transmission. In addition to introducing a promising diagnostic tool, this study provides the in vivo evidence that protective antibodies may prevent infection by HIV.

引用

页码：3445 / 3449

页数：5

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