NMDA RECEPTOR-DEPENDENT LONG-TERM POTENTIATION IN THE HIPPOCAMPAL AFFERENT FIBER SYSTEM TO THE PREFRONTAL CORTEX IN THE RAT

被引：154
作者：
JAY, TM [1 ]
BURETTE, F [1 ]
LAROCHE, S [1 ]
机构：
[1] COLL FRANCE,INSERM,U114,F-75231 PARIS 05,FRANCE
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 1995年 / 7卷 / 02期
关键词：
PRELIMBIC CORTEX; D-AP5; SUBICULUM; CA1;
D O I：
10.1111/j.1460-9568.1995.tb01060.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study investigated the role of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in the induction of long-term potentiation (LTP) in the hippocampal-prefrontal cortex pathway in vivo. Field potentials evoked by electrical stimulation of the CA1/subicular region were recorded in the prelimbic area of the prefrontal cortex under continuous perfusion of artificial cerebrospinal fluid in anaesthetized rats. High-frequency stimulation of the CA1/subicular region induced LTP of the evoked response in the prelimbic area of the prefrontal cortex. LTP was completely blocked when the selective NMDA receptor antagonist D-(-)2-amino-5-phosphonopentanoic acid (D-AP5; 200 mu M), was perfused during the tetanus. Perfusion of D-AP5 did not affect normal transmission or pre-established LTP. These results demonstrate that induction of LTP in the hippocampal-prefrontal cortex pathway is an NMDA receptor-dependent process.
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收藏
页码：247 / 250
页数：4
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