NMDA RECEPTOR-DEPENDENT LONG-TERM POTENTIATION IN THE HIPPOCAMPAL AFFERENT FIBER SYSTEM TO THE PREFRONTAL CORTEX IN THE RAT

被引：154

作者：

JAY, TM ^{[1
]}

BURETTE, F ^{[1
]}

LAROCHE, S ^{[1
]}

机构：

[1] COLL FRANCE,INSERM,U114,F-75231 PARIS 05,FRANCE

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1995年 / 7卷 / 02期

关键词：

PRELIMBIC CORTEX; D-AP5; SUBICULUM; CA1;

D O I：

10.1111/j.1460-9568.1995.tb01060.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the role of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in the induction of long-term potentiation (LTP) in the hippocampal-prefrontal cortex pathway in vivo. Field potentials evoked by electrical stimulation of the CA1/subicular region were recorded in the prelimbic area of the prefrontal cortex under continuous perfusion of artificial cerebrospinal fluid in anaesthetized rats. High-frequency stimulation of the CA1/subicular region induced LTP of the evoked response in the prelimbic area of the prefrontal cortex. LTP was completely blocked when the selective NMDA receptor antagonist D-(-)2-amino-5-phosphonopentanoic acid (D-AP5; 200 mu M), was perfused during the tetanus. Perfusion of D-AP5 did not affect normal transmission or pre-established LTP. These results demonstrate that induction of LTP in the hippocampal-prefrontal cortex pathway is an NMDA receptor-dependent process.

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页码：247 / 250

页数：4

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