A NEW ALPHA-AMINO-ACID GAMMA-ANION EQUIVALENT - DIRECT SYNTHESIS OF ENANTIOMERICALLY PURE PROTECTED AMINO-ACIDS

被引：0

作者：

JACKSON, RFW ^{[1
]}

WISHART, N ^{[1
]}

WYTHES, MJ ^{[1
]}

机构：

[1] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

SYNLETT | 1993年 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of the glutamic acid derived iodide 7 with Rieke copper at -78-degrees-C generates the functionalised alkyl copper reagent 6b, an alpha-amino acid gamma-anion equivalent, which reacts directly with acid chlorides and allylic chlorides at -30-degrees-C to give the products of substitution 10-12. In two cases, the enantiomeric purity of the products was established by comparison of optical rotation data with literature values, indicating that the coupling process occurs without racemisation.

引用

页码：219 / 220

页数：2

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