5-HT1A-AGONISTIC PROPERTIES OF NAFTOPIDIL, A NOVEL ANTIHYPERTENSIVE DRUG

被引：19

作者：

BORBE, HO ^{[1
]}

METZENAUER, P ^{[1
]}

SZELENYI, I ^{[1
]}

机构：

[1] ASTA PHARMA AG,DEPT PHARMACOL,W-6000 FRANKFURT,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 205卷 / 01期

关键词：

NAFTOPIDIL; URAPIDIL; 8-OH-DPAT (8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN); SPIROXATRINE; 5-HT1A RECEPTORS; BLOOD PRESSURE; (CAT);

D O I：

10.1016/0014-2999(91)90779-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Naftopidil, a novel antihypertensive compound, possesses 5-HT1A agonistic properties in addition to being an alpha-1-adrenoceptor antagonist. The IC50 values for alpha-1-adrenoceptors (235 nmol/l) and for 5-HT1A receptors (108 nmol/l) lie in the same concentration range. The reduction in blood pressure of anesthetized cats by 8-OH-DPAT and urapidil was completely abolished by spiroxatrine, a 5-HT1A antagonist. However, the decreases in blood pressure induced by naftopidil were only partly antagonized by spiroxatrine.

引用

页码：105 / 107

页数：3

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