Research has shown that African-American men have a higher incidence, a higher death rate, and a lower survival rate for most cancers. But currently there are few studies addressing factors influencing the health care trends of this high-risk population. A study focused on identifying factors that contribute to early cancer detection and cancer risk-reduction health behavior in African-American men was therefore implemented. There is evidence to support the conclusion that perceptions do significantly contribute to the health behavior of African-American men. Those having the greatest impact were related to methods of early cancer screening. Clearly, if the National Cancer Institute's goal to reduce the mortality from cancer in the general population by 50% from the base rate in 1984 is to be met by the year 2000, there must be an increase in programs targeting African-American men. Every day African-American men can take steps to help protect themselves from cancer. Our charge as health care clinicians, educators, and researchers is to pinpoint ways to encourage them to do so.