EFFECT OF ALTERATION OF RAT HEPATIC MIXED-FUNCTION OXIDASE (MFO) ACTIVITY ON TOXICITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD)

被引：76
作者：
BEATTY, PW
VAUGHN, WK
NEAL, RA
机构：
[1] Center in Environmental Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 1978年 / 45卷 / 02期
关键词：
D O I：
10.1016/0041-008X(78)90113-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of alteration of the activity of the hepatic mixed-function oxidase (MFO) enzyme systems on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats has been examined. These experiments have indicated the naturally occurring age and sex-related differences in hepatic MFO activity in rats are inversely correlated with the 20-day LD50 of TCDD in these animals. The effect of administering inducers and inhibitors of the hepatic MFO enzyme systems on the 20-day LD50 of TCDD in rats has also been examined. In all cases there was an inverse relationship between the activity of the hepatic MFO system at the time of TCDD administration and the toxicity of TCDD as determined by the 20-day LD50. © 1978.
引用
收藏
页码：513 / 519
页数：7
相关论文
共 25 条
[1]   TISSUE DISTRIBUTION, EXCRETION AND BIOLOGICAL EFFECTS OF [C-14]TETRACHLORODIBENZO-PARA-DIOXIN IN RATS [J].
ALLEN, JR ;
VANMILLER, JP ;
NORBACK, DH .
FOOD AND COSMETICS TOXICOLOGY, 1975, 13 (05) :501-&
[2]   INFLUENCE OF FASTING AND HEMIN ON MICROSOMAL CYTOCHROMES AND ENZYMES [J].
BOCK, KW ;
FROHLING, W ;
REMMER, H .
BIOCHEMICAL PHARMACOLOGY, 1973, 22 (13) :1557-1564
[3]  
BRODIE BB, 1948, J PHARMACOL EXP THER, V94, P29
[4]  
COCHIN J, 1959, J PHARMACOL EXP THER, V125, P105
[5]  
CONNEY AH, 1967, PHARMACOL REV, V19, P317
[6]  
CRUMMETT W B, 1973, Environmental Health Perspectives, V5, P15, DOI 10.2307/3428109
[7]   MULTIPLE COMPARISON METHODS FOR COMPARING REGRESSION COEFFICIENTS [J].
DUNCAN, DB .
BIOMETRICS, 1970, 26 (01) :141-&
[8]  
FINNEY DJ, 1971, PROBIT ANAL, P66
[9]  
GIELEN JE, 1972, J BIOL CHEM, V247, P1125
[10]   MIXED-FUNCTION OXIDASES AND ALVEOLAR MACROPHAGE [J].
HOOK, GER ;
BEND, JR ;
FOUTS, JR .
BIOCHEMICAL PHARMACOLOGY, 1972, 21 (24) :3267-&
123