PERIPHERAL ADMINISTRATION OF LIPOPOLYSACCHARIDE INDUCES THE EXPRESSION OF CYTOKINE TRANSCRIPTS IN THE BRAIN AND PITUITARY OF MICE

被引：427

作者：

LAYE, S ^{[1
]}

PARNET, P ^{[1
]}

GOUJON, E ^{[1
]}

DANTZER, R ^{[1
]}

机构：

[1] INRA, INSERM, U394, F-33077 BORDEAUX, FRANCE

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 27卷 / 01期

关键词：

INTERLEUKIN-1; INTERLEUKIN-6; TUMOR NECROSIS FACTOR; LIPOPOLYSACCHARIDE; BRAIN; PITUITARY; SEMIQUANTITATIVE RT-PCR; SICKNESS BEHAVIOR;

D O I：

10.1016/0169-328X(94)90197-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The reverse transcription polymerase chain reaction (RT-PCR) was used to assess the induction of mRNA of the proinflammatory cytokines IL-1 beta, IL-6 and TNF alpha in the spleen, pituitary, hypothalamus and hippocampus of mice after an intraperitoneal injection of lipopolysaccharide (LPS, 10 mu g/mouse). The kinetics of cytokine gene expression induced by peripheral LPS in the pituitary and brain structures were different from that observed in the spleen. For IL-1 beta the dose-response curve was also measured and also found to be different. These results support the idea that one pathway by which peripheral immune stimuli affect brain functions includes local synthesis of proinflammatory cytokines in certain brain structures.

引用

页码：157 / 162

页数：6

共 33 条

[1] BRAIN INTERLEUKIN-1 GENE-EXPRESSION INDUCED BY PERIPHERAL LIPOPOLYSACCHARIDE ADMINISTRATION [J].