QUANTITATIVE FOURIER-TRANSFORM INFRARED ATTENUATED TOTAL REFLECTANCE ANALYSIS OF KETOPROFEN IN SOME PHARMACEUTICAL FORMULATIONS

An overhead attenuated total reflectance system was used to quantify ketoprofen in some pharmaceutical formulations (capsules and injection ampoules). No extensive sample pretreatment was needed. The ampoules were analysed as such and a simultaneous quantification of ketoprofen and arginine base was performed. A partial least-squares package (PLS1) was applied to the calibration and prediction for a limited number of standard solutions.