PLASTICITY OF EXCITATORY SYNAPTIC TRANSMISSION IN KITTEN VISUAL-CORTEX DEPENDS ON VOLTAGE-DEPENDENT CA2+ CHANNELS BUT NOT ON NMDA RECEPTORS

被引：12
|
作者：
KOMATSU, Y
机构：
[1] Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, 602, Kawaramachi-Hirokoji
来源：
NEUROSCIENCE RESEARCH | 1994年 / 20卷 / 03期
关键词：
LONG-TERM POTENTIATION; EXCITATORY SYNAPTIC TRANSMISSION; NMDA RECEPTOR; CALCIUM CHANNEL; VISUAL CORTEX; DEVELOPMENTAL PLASTICITY;
D O I：
10.1016/0168-0102(94)90089-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) of excitatory synaptic transmission occurs in in vitro slices of cat and rat visual cortex. Earlier studies suggested that activation of N-methyl-D-aspartate (NPMDA)-selective glutamate receptors is essential for the induction of LTP. However, our studies on kitten visual cortex demonstrate that LTP induction requires the activation of low-threshold Ca2+ channels in postsynaptic cells but not of NMDA receptors.
引用
收藏
页码：209 / 212
页数：4
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