DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF CHIRAL SECONDARY ALCOHOLS - NEW ADVANCES USING C-13-NMR AND 2D-NMR SPECTROSCOPY

被引：35

作者：

PEHK, T

LIPPMAA, E

LOPP, M

PAJU, A

BORER, BC

TAYLOR, RJK

机构：

[1] TALLINN CHEM INST,TALLINN 0108,ESTONIA

[2] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)80354-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The use of H-1-C-13 and H-1-H-1 2D COSY correlation experiments substantially enhances the potential of the NMR procedure for determining the absolute configuration of chiral secondary alcohols via their diastereomeric MPA and/or MTPA esters. Phenyl ring current effects are observed over remarkably long distances and comparable effects are seen for both C-13 and H-1 chemical shifts. The use of C-13 chemical shifts to aid configurational assignment is particularly valuable.

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页码：1527 / 1532

页数：6

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