RELATIONSHIP BETWEEN SUPEROXIDE-DISMUTASE AND MELANIN IN A PATHOGENIC FUNGUS

被引：52

作者：

JACOBSON, ES ^{[1
]}

JENKINS, ND ^{[1
]}

TODD, JM ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,DEPT INTERNAL MED,RICHMOND,VA 23298

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 09期

关键词：

D O I：

10.1128/IAI.62.9.4085-4086.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.

引用

页码：4085 / 4086

页数：2

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