RELATIONSHIP BETWEEN SUPEROXIDE-DISMUTASE AND MELANIN IN A PATHOGENIC FUNGUS

被引:52
作者
JACOBSON, ES [1 ]
JENKINS, ND [1 ]
TODD, JM [1 ]
机构
[1] VIRGINIA COMMONWEALTH UNIV,DEPT INTERNAL MED,RICHMOND,VA 23298
关键词
D O I
10.1128/IAI.62.9.4085-4086.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.
引用
收藏
页码:4085 / 4086
页数:2
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