ANTITUMOR EFFECT OF A BIOLOGICAL RESPONSE MODIFIER, PSK, ON C57BL/6 MICE WITH SYNGENEIC MELANOMA B16 AND ITS MODE OF ACTION

被引：0

作者：

MATSUNAGA, K ^{[1
]}

AOTA, M ^{[1
]}

NYUNOYA, Y ^{[1
]}

HAKOZAKI, M ^{[1
]}

ISHIKAWA, Y ^{[1
]}

OHHARA, M ^{[1
]}

SUGITA, N ^{[1
]}

ENDO, H ^{[1
]}

机构：

[1] TOTTORI UNIV,FAC MED,SCH LIFE SCI,DEPT MOLEC BIOL,YONAGO,TOTTORI 683,JAPAN

来源：

ONCOLOGY | 1994年 / 51卷 / 04期

关键词：

B16; MELANOMA; PSK; CYTOSTASIS; INTERLEUKIN; 1;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of PSK, a protein-bound polysaccharide, on the survival period and effector cell activity were examined using C57BL/6 mice with melanoma B16. PSK prolonged the survival period of the mice with tumors in a schedule- and dose-dependent manner. However, no life-prolonging effect was observed when carrageenan-treated mice or congenitally athymic mice were used as hosts. PSK enhanced the cytostatic activity and interleukin-1-producing capacity of peritoneal exudate plastic-adherent cells in C57BL/6 mice with tumors. These findings suggested that PSK prolongs the survival period of mice with B16 tumors through T-cell- and macrophage-dependent mechanisms.

引用

页码：303 / 308

页数：6