NONCONDITIONAL REPLICATION-DEFECTIVE MUTANT OF THE SCHMIDT-RUPPIN STRAIN OF ROUS-SARCOMA VIRUS

被引：2

作者：

VOGT, PK ^{[1
]}

HAYMAN, M ^{[1
]}

HUNTER, E ^{[1
]}

DUESBERG, PH ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC BIOL,BERKELEY,CA 94720

来源：

VIROLOGY | 1979年 / 92卷 / 02期

关键词：

D O I：

10.1016/0042-6822(79)90133-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A nonconditional mutant of the Schmidt-Ruppin strain of Rous sarcoma virus (subgroup A) that fails to synthesize infectious progeny virus is described. Nonproducing cells transformed by this mutant LA7365 have functional viral src and env genes. The gag gene of LA7365 is defective. There is no complementation with a gag ts mutant, and pulse-chase experiments show that the proteolytic processing of the gag precursor pr76 is strongly inhibited in mutant-infected cells. Whether there is an additional lesion in the pol gene of LA 7365 could not be determined from the available data. © 1979.

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页码：285 / 290

页数：6

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