IMMUNOLOGICAL EVIDENCE FOR THE PRESENCE IN SEA-URCHIN EMBRYOS OF A CELL-ADHESION PROTEIN SIMILAR TO MOUSE UVOMORULIN (E-CADHERIN)

被引：13

作者：

GHERSI, G ^{[1
]}

VITTORELLI, ML ^{[1
]}

机构：

[1] DEPT CELLULAR & DEV BIOL,PALERMO,ITALY

来源：

CELL DIFFERENTIATION AND DEVELOPMENT | 1990年 / 31卷 / 01期

关键词：

Cadherin; CAM; Sea urchin embryo; Uvomorulin;

D O I：

10.1016/0922-3371(90)90091-A

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A tryptic fragment (88 kDa), obtained from external digestion of sea urchin embryos carried out in the presence of calcium, shows immunological cross-reactivity with polyclonal and monoclonal antibodies (DECMA-1) against mouse teratocarcinoma uvomorulin. Fab fragments obtained from anti-mouse terato-carcinoma uvomorulin mono- and polyclonal antibodies, and from polyclonal antibodies against the partially purified 88-kDa tryptic fragment, decompact early sea urchin embryos and block reaggregation of dissociated sea urchin blastula cells. These data indicate the presence of an uvomorulin-like protein in sea urchin embryos and suggest an important role for this protein in embryonic development. © 1990.

引用

页码：67 / 75

页数：9