AFFERENT SYNAPTIC CHANGES IN AUDITORY HAIR-CELLS DURING NOISE-INDUCED TEMPORARY THRESHOLD SHIFT

被引:33
作者
HENRY, WR [1 ]
MULROY, MJ [1 ]
机构
[1] MED COLL GEORGIA, DEPT CELLULAR BIOL & ANAT, AUGUSTA, GA 30912 USA
关键词
COCHLEA; HAIR CELL; NOISE-INDUCED HEARING LOSS; TTS; ALLIGATOR LIZARD; SYNAPSE; SYNAPTIC BODY;
D O I
10.1016/0378-5955(95)00014-U
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
This study presents evidence in support of the hypothesis that one of the sites of failure during noise-induced temporary threshold shift (TTS) is the afferent synapse between auditory hair cells and auditory nerve fibers. Our results show clear evidence indicating changes in the quantity of afferent synapses and the morphology of presynaptic structures in the alligator lizard auditory hair cells during TTS. In TTS hair cells there are statistically significant decreases in: 1) the number of afferent synapses, 2) the number of synaptic vesicles at the afferent synapses, 3) the size of synaptic bodies, and 4) the packing density of synaptic vesicles around the synaptic body. These results suggest that the presynaptic components of the afferent synapse reflect the functional state of the synapse, and that the reduction of these synapses, both in number and component size, contributes to TTS.
引用
收藏
页码:81 / 90
页数:10
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