Fondaparinux treatment in heparin induced thrombocytopenia: a case report

被引:1
作者
Ozsu, Savas [1 ]
Korkmaz, Ahmet [1 ]
Bulbul, Yilmaz [1 ]
Oztuna, Funda [1 ]
Ozlu, Tevfik [1 ]
机构
[1] Karadeniz Tech Univ, Tip Fak, Gogus Hastaliklari Anabilim Dali, Trabzon, Turkey
来源
TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | 2011年 / 59卷 / 02期
关键词
Dalteparin; fondaparinux; heparin induced thrombocytopenia; pulmonary thromboembolism;
D O I
10.5578/tt.1692
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Heparin induced thrombocytopenia is a serious complication of heparin therapy that has a high levels of morbidity and mortality due to thrombotic complications. Heparin induced thrombocytopenia usually develops between days 5 and 14 (inclusive) following initiation of heparin. When heparin induced thrombocytopenia is suspected, heparin should be discontinued and treatment with a direct thrombin inhibitor should be initiated. Heparin induced thrombocytopenia occurs more frequently with unfractionated heparin than with low molecular weight heparin. In this manuscript, we presented a case diagnosis with heparin induced thrombocytopenia who was given low molecular weight heparin for prophylaxis. We tried to make an overview of new treatment choices along with current literature.
引用
收藏
页码:178 / 183
页数:6
相关论文
共 33 条
[1]  
Akagun T, 2006, INT J HEMATOLOGY ONC, V16, P141
[2]  
Baglin TP, 1997, PLATELETS, V8, P72
[3]   New anticoagulants [J].
Bauer, Kenneth A. .
CURRENT OPINION IN HEMATOLOGY, 2008, 15 (05) :509-515
[4]  
BRADNER J, 2004, BLOOD, V104, P1775
[5]   Heparin-induced thrombocytopenia [J].
Chong, BH .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (07) :1471-1478
[6]   Incidence of antiheparin-platelet factor 4 antibodies and heparin-induced thrombocytopenia in Turkish patients undergoing cardiac surgery [J].
Demir, Muzaffer ;
Duran, Enver ;
Yigitbasi, Omer ;
Vural, Ozden ;
Kurum, Turhan ;
Yuksel, Mahmut ;
Turgut, Burhan ;
Walenga, Jeanine M. ;
Fareed, Jawed .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2007, 13 (03) :279-284
[7]   A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia [J].
Farner, B ;
Eichler, P ;
Kroll, H ;
Greinacher, A .
THROMBOSIS AND HAEMOSTASIS, 2001, 85 (06) :950-957
[8]   Heparin-induced thrombocytopenia: An update [J].
Franchini M. .
Thrombosis Journal, 3 (1)
[9]  
Hassell K, 2008, THROMB RES, V123, pS16, DOI 10.1016/j.thromres.2008.08.013
[10]   Treatment of heparin-induced thrombocytopenia - A critical review [J].
Hirsh, J ;
Heddle, N ;
Kelton, JG .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (04) :361-369