MSAFP LEVELS AND ESOPHAGEAL ATRESIA

被引：4

作者：

CHODIRKER, BN

CHUDLEY, AE

MACDONALD, KM

HARMAN, CR

EVANS, JA

机构：

[1] UNIV MANITOBA,DEPT HUMAN GENET,WINNIPEG,MB,CANADA

[2] UNIV MANITOBA,DEPT PEDIAT & CHILD HLTH,WINNIPEG R3T 2N2,MB,CANADA

[3] UNIV MANITOBA,DEPT OBSTET GYNECOL & REPROD SCI,WINNIPEG R3T 2N2,MB,CANADA

[4] HLTH SCI CTR,WINNIPEG,MB,CANADA

来源：

PRENATAL DIAGNOSIS | 1994年 / 14卷 / 11期

关键词：

ESOPHAGEAL ATRESIA; TRACHEOESOPHAGEAL FISTULA; MATERNAL SERUM ALPHA-FETOPROTEIN (MSAFP);

D O I：

10.1002/pd.1970141114

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This study was undertaken to evaluate the relationship between maternal serum alpha-fetoprotein (MSAFP) levels and oesophageal atresia (OA). OA occurred in 16 fetuses of mothers who had an MSAFP test in the study interval. The multiple of the median (MOM) value for MSAFP averaged 1.54 +/- 0.65 (range 0.5-2.9 MOM), which was significantly higher than the value seen in controls. The median MOM was 1.35. Using a cut-off of 2.5 MOM, the sensitivity of MSAFP for detecting OA was 19 per cent. Although OA should be considered in the differential diagnosis of an elevated MSAFP level, MSAFP cannot be considered an appropriate screening test for OA given the low sensitivity.

引用

页码：1086 / 1089

页数：4

共 9 条

[1]

BURTON BK, 1988, OBSTET GYNECOL, V72, P709

[2]

CHODIRKER BN, 1993, CURRENT PRACTICE PRE, V13

[3] THE EPIDEMIOLOGY OF TRACHEOESOPHAGEAL FISTULA AND ESOPHAGEAL ATRESIA IN EUROPE [J].