HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED MYOPATHY - ANALYSIS OF 11 PATIENTS

被引:184
作者
SIMPSON, DM
BENDER, AN
机构
[1] MT SINAI MED CTR, DEPT CLIN NEUROPHYSIOL, BOX 1052, 1 GUSTAVE L LEVY PL, NEW YORK, NY 10029 USA
[2] MT SINAI MED CTR, DEPT NEUROL, NEW YORK, NY 10029 USA
关键词
D O I
10.1002/ana.410240114
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neuromuscular disorders reported in association with human immunodeficiency virus (HIV) infection include several forms of peripheral neuropathy and polymyositis. We report 11 patients with HIV-associated myopathy. Five patients with acquired immunodeficiency syndrome (AIDS), 2 with AIDS-related complex, and 4 otherwise asymptomatic HIV-infected patients developed progressive proximal muscle weakness. Serum creatine phosphokinase levels were elevated and electromyography revealed abnormal spontaneous activity and myopathy in most patients. All 8 muscle biopsy specimens showed fiber necrosis. Four had inflammatory infiltrates, and nemaline rod bodies were prominent in 3. Immunosuppressant therapy in 5 patients resulted in improvement. Attempts at viral localization in 4 muscle biopsy specimens were unsuccessful. These findings suggest a distinct association between HIV infection and myopathy with features atypical for polymyositis.
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页码:79 / 84
页数:6
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