Sarcoidosis patient with lupus pernio and infliximab-induced myositis: Response to Acthar gel

被引：11
作者：
Zhou, Ying [1 ,2 ]
Lower, Elyse E. [1 ]
Li, Huiping [2 ]
Baughman, Robert P. [1 ]
机构：
[1] Univ Cincinnati, Med Ctr, Dept Internal Med, 1001 Holmes,Eden Ave, Cincinnati, OH 45267 USA
[2] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Resp Med, Shanghai 200433, Peoples R China
来源：
RESPIRATORY MEDICINE CASE REPORTS | 2016年 / 17卷
关键词：
Sarcoidosis; Myositis; Infliximab; Acthar;
D O I：
10.1016/j.rmcr.2015.11.001
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Infliximab is an effective treatment for sarcoidosis patients with persistent disease despite glucocorticoids and immunosuppressive therapy. Patients receiving infliximab can experience side effects, inducing an autoimmune reaction. Treatment is unclear for sarcoidosis patients who develop autoimmune reactions to infliximab. We report a case of a patient with advanced sarcoidosis who developed a myositis type reaction to infliximab characterized by diffuse muscle achiness and weakness and marked elevations in serum creatinine phosphokinase (CPK) and aldolase. Manifestations of sarcoidosis and myositis improved after Acthar treatment. This is the first report of successful treatment with Acthar in a patient with advanced sarcoidosis with an autoimmune reaction to infliximab. (C) 2015 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：5 / 7
页数：3
相关论文
共 29 条
  • [1] Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis
    Arnason, Barry G.
    Berkovich, Regina
    Catania, Anna
    Lisak, Robert P.
    Zaidi, Mone
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (02) : 130 - 136
  • [2] Baughman R.P., 2015, RESPIR MED IN PRESS
  • [3] Chronic facial sarcoidosis including lupus pernio - Clinical description and proposed scoring systems
    Baughman, Robert P.
    Judson, Marc A.
    Teirstein, Alvin
    Lower, Elyse E.
    Lo, Kim
    Schlenker-Herceg, Rozsa
    Barnathan, Elliot S.
    [J]. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2008, 9 (03) : 155 - 161
  • [4] Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement
    Baughman, Robert P.
    Drent, Marjolein
    Kavuru, Mani
    Judson, Marc A.
    Costabel, Ulrich
    du Bois, Roland
    Albera, Carlo
    Brutsche, Martin
    Davis, Gerald
    Donohue, James F.
    Mueller-Quernheim, Joachim
    Schlenker-Herceg, Rozsa
    Flavin, Susan
    Lo, Kim Hung
    Oemar, Barry
    Barnathan, Elliot S.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (07) : 795 - 802
  • [5] Established and experimental medical therapy of pulmonary sarcoidosis
    Baughman, Robert P.
    Nunes, Hilario
    Sweiss, Nadera J.
    Lower, Elyse E.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2013, 41 (06) : 1424 - 1438
  • [6] Baughman RP, 2000, SARCOIDOSIS VASC DIF, V17, P60
  • [7] Oral ACTH (H.P. Acthar®Gel) inhibits IL-1 and IL-17 secretion in humans
    Brod, Staley A.
    Bauer, Victoria
    Hood, Zachary
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2012, 66 (01) : 36 - 39
  • [8] A high incidence of disease flares in an open pilot study of infliximab in patients with refractory inflammatory myopathies
    Dastmalchi, M.
    Grundtman, C.
    Alexanderson, H.
    Mavragani, C. P.
    Einarsdottir, H.
    Helmers, S. Barbasso
    Elvin, K.
    Crow, M. K.
    Nennesmo, I.
    Lundberg, I. E.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (12) : 1670 - 1677
  • [9] Drent M, 2014, SARCOIDOSIS VASC DIF, V31, P91
  • [10] A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies
    Eloranta, Maija-Leena
    Helmers, Sevim Barbasso
    Ulfgren, Ann-Kristin
    Ronnblom, Lars
    Alm, Gunnar V.
    Lundberg, Ingrid E.
    [J]. ARTHRITIS AND RHEUMATISM, 2007, 56 (09): : 3112 - 3124
123