TAXUSPINE-D, A NEW TAXANE DITERPENE FROM TAXUS-CUSPIDATA WITH POTENT INHIBITORY ACTIVITY AGAINST CA2+-INDUCED DEPOLYMERIZATION OF MICROTUBULES

被引：52

作者：

KOBAYASHI, J ^{[1
]}

HOSOYAMA, H ^{[1
]}

SHIGEMORI, H ^{[1
]}

KOISO, Y ^{[1
]}

IWASAKI, S ^{[1
]}

机构：

[1] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

EXPERIENTIA | 1995年 / 51卷 / 06期

关键词：

TAXOID; TAXUSPINE D; YEW; TAXUS CUSPIDATA; MICROTUBULE DEPOLYMERIZATION;

D O I：

10.1007/BF02128750

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate moiety, has been isolated from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc., and the structure elucidated on the basis of spectroscopic data. Taxuspine D (1) markedly inhibited Ca2+-induced depolymerization of microtubules.

引用

页码：592 / 595

页数：4

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