INHIBITION OF PLATELET-AGGREGATION UNDER THE ACTION OF SODIUM-HYPOCHLORITE - EFFECT OF BLOOD-PLASMA COMPONENTS

被引：0
|
作者：
MURINA, MA
TRUNILINA, NN
ROSHCHUPKIN, DI
SARKINA, EE
SERGIENKO, VI
机构：
[1] MINIST HLTH RUSSIA,INST PHYSICOCHEM MED,MOSCOW,RUSSIA
[2] RUSSIAN STATE MED UNIV,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 05期
关键词：
PLATELETS; AGGREGATION; SODIUM HYPOCHLORITE; PLASMA; CHLORAMINE; AMINO ACIDS;
D O I：
10.1007/BF02543432
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The proteins fibrinogen and serum albumin and the amino acid alanine modified by sodium hypochlorite are shown to inhibit thrombin-induced aggregation of isolated platelets. The hypochlorite sodium-treated proteins and amino acids acquire the capacity to counter platelet aggregation as a result of the formation of chloramine derivatives. The aggregating capacity of hypochlorite sodium-inactivated platelets can be restored by native plasma and fibrinogen.
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收藏
页码：471 / 473
页数：3
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