FURTHER CHARACTERIZATION OF THE 5'-FLANKING REGION OF THE RAT LACTASE-PHLORHIZIN HYDROLASE GENE

被引：19

作者：

VERHAVE, M ^{[1
]}

KRASINSKI, SD ^{[1
]}

MAAS, SM ^{[1
]}

SMIERS, FJW ^{[1
]}

MISHRA, K ^{[1
]}

BREEUWSMA, NG ^{[1
]}

NAIM, HY ^{[1
]}

GRAND, RJ ^{[1
]}

机构：

[1] UNIV DUSSELDORF, INST MICROBIOL, DUSSELDORF, GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1595

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lactase-phlorizin hydrolase gene is widely used as a marker of intestinal differentiation. Recent evidence demonstrating that transcription plays a major role in the regulation of this gene suggests that study of the 5'-flanking region will allow an understanding of how the expression of this gene is controlled. However, sequence, restriction, and primer extension analysis of a rat genomic clone has revealed that previously published data are incomplete. In the present study, we used a directed sequencing strategy to carefully analyze this region. Our expanded analysis of the 5'-flanking region of the lactase-phlorizin hydrolase gene should facilitate future studies of its structure and function. (C) 1995 Academic Press, Inc.

引用

页码：989 / 995

页数：7

共 22 条

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[2]

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