SELECTIVE LABELING OF PEPTIDES USING (DIENYL) IRON TRICARBONYL CATIONS

被引：23
作者：
CARVER, JA
FATES, B
KANEMAGUIRE, LAP
机构：
来源：
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 11期
关键词：
D O I：
10.1039/c39930000928
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dienyl cations of the type [(eta5-R.C6H6)Fe(CO)3]+ 1 are shown to be versatile electrophilic reagents for the rapid and selective labelling of peptides and proteins, with the affinity for amino acid residues decreasing markedly in the order: cys (SH) > his (-N=) > glu (delta-CO2-) >> alpha-NH2, lys (epsilon-NH2), ser (gamma-OH), asn (-CONH).
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页码：928 / 929
页数：2
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