CLINICAL DETECTION OF BCR-ABL FUSION BY INSITU HYBRIDIZATION IN CHRONIC MYELOGENOUS LEUKEMIA

被引：29

作者：

AMIEL, A

YARKONI, S

FEJGIN, M

GABER, E

NAGLER, A

MANOR, Y

LISHNER, M

机构：

[1] HADASSAH UNIV HOSP,DEPT BONE MARROW TRANSPLANTAT,JERUSALEM,ISRAEL

[2] MEIR HOSP,HEMATOL UNIT,IL-44281 KEFAR SAVA,ISRAEL

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 65卷 / 01期

关键词：

D O I：

10.1016/0165-4608(93)90055-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous leukemia (CML) after aggressive cytoreductive treatment. The analysis was made in interphase nuclei because of the very small number of recognizable metaphases in leukemic patients. FISH was a reliable tool for the detection of chromosome translocations in interphase nuclei as compared with conventional cytogenetic and polymerase chain reaction (PCR) techniques.

引用

页码：32 / 34

页数：3

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