CIRCULATING LEVELS OF IGG1 AND IGG4 ANTI-IGE ANTIBODIES AND ASTHMA SEVERITY

被引：13

作者：

SHAKIB, F

SIHOE, J

SMITH, SJ

WILDING, P

CLARK, MM

KNOX, A

机构：

[1] UNIV NOTTINGHAM, FAC MED, DEPT IMMUNOL, NOTTINGHAM, ENGLAND

[2] UNIV NOTTINGHAM, FAC MED, RESP MED UNIT, NOTTINGHAM, ENGLAND

来源：

ALLERGY | 1994年 / 49卷 / 03期

基金：

英国惠康基金;

关键词：

ALLERGY; ASTHMA; AUTOANTIBODY; IGE; IGG1; IGG4;

D O I：

10.1111/j.1398-9995.1994.tb00825.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In this paper, we have determined the levels of IgG1 and IgG4 anti-IgE in the sera of 66 asthma patients suffering from mild (n = 24), moderate (n = 23), or severe (n = 19) symptoms, and 20 nonatopic, healthy subjects. The study has revealed that although asthma patients have significantly elevated levels of IgG1 and IgG4 anti-IgE antibodies, the concentration of these autoantibodies is not related to the severity of asthma. This conclusion may be related to the known heterogeneity of autoanti-IgE antibodies in terms of their ability to trigger basophil histamine release.

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收藏

页码：192 / 195

页数：4

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