RADIATION HYBRID MAP SPANNING THE HUNTINGTON DISEASE GENE REGION OF CHROMOSOME-4

被引：20

作者：

ALTHERR, MR

PLUMMER, S

BATES, G

MACDONALD, M

TAYLOR, S

LEHRACH, H

FRISCHAUF, AM

GUSELLA, JF

BOEHNKE, M

WASMUTH, JJ

机构：

[1] UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717

[2] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

[3] MASSACHUSETTS GEN HOSP,CTR NEUROSCI,BOSTON,MA 02114

[4] UNIV MICHIGAN,DEPT BIOSTAT,ANN ARBOR,MI 48109

来源：

GENOMICS | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90017-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Radiation hybrid (RH) mapping was used to construct a map of 11 markers in the distal 4 Mb of the short arm of chromosome 4, the region containing the Huntington disease gene. Two different methods for deriving the order of the markers were compared and both arrived at the same order as being the most likely. This order is also consistent with both the physical map constructed using pulsed-field gel electrophoresis (PFGE) and the meiotic linkage map. Comparing the RH map to the map determined by PFGE provided the means to equate RH map units (centirays) with actual physical distance in kilobases of DNA. In addition, a simple procedure for reducing the complexity of human DNA in radiation hybrids is described. One cell line isolated using this procedure contains, as its only human DNA, ∼2 Mb surrounding the Huntington disease gene. © 1992.

引用

页码：1040 / 1046

页数：7

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