MODULATION OF LEVELS OF MESSENGER-RNA FOR TISSUE-TYPE PLASMINOGEN-ACTIVATOR IN RAT SERTOLI CELLS, AND LEVELS OF MESSENGER-RNA FOR PLASMINOGEN-ACTIVATOR INHIBITOR IN TESTIS PERITUBULAR CELLS

被引：44
|
作者：
NARGOLWALLA, C [1 ]
MCCABE, D [1 ]
FRITZ, IB [1 ]
机构：
[1] UNIV TORONTO, BANTING & BEST DEPT MED RES, 112 COLL ST, TORONTO M5G 1L6, ONTARIO, CANADA
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1990年 / 70卷 / 01期
基金：
英国医学研究理事会;
关键词：
(Rat); Follicle-stimulating hormone; Peritubular myoid cell; Plasminogen activator; Plasminogen activator inhibitor; Protease; Sertoli cell; Testis; Transcriptional control; Transforming growth factor β[!sub]1[!/sub;
D O I：
10.1016/0303-7207(90)90060-L
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Messenger RNA for tissue-type plasminogen activator has been detected in RNA extracts from rat Sertoli cells in culture. Relative levels are increased in Sertoli cells stimulated by follicle-stimulating hormone or by dibutyryl cyclic AMP (dbcAMP) and decreased in cells maintained in the presence of transforming growth factor beta, type l (TGF-β1). Messenger RNA for plasminogen activator inhibitor, type 1 (PAI-1) has been detected in RNA extracts from rat peritubular myoid cells. Relative levels are increased in peritubular cells stimulated by TGF-β1, and decreased by the presence of dbcAMP in the medium. Data are interpreted to indicate that net protease activities in the seminiferous tubule are regulated at transcriptional levels by endocrine and paracrine agents. © 1990.
引用
收藏
页码：73 / 80
页数：8
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