Lung cancer and epigenetic modifications

被引：12

作者：

Yuce, Gulbahar Darilmaz ^{[1
]}

Ersoy, Ebru Ortac ^{[2
]}

机构：

[1] Turgut Ozal Univ, Dept Chest Dis, Fac Med, Ankara, Turkey

[2] Hacettepe Univ, Intens Care Unit, Fac Med, Ankara, Turkey

来源：

TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | 2016年 / 64卷 / 02期

关键词：

Lung cancer; epigenetics; chromatin; histone modifications; DNA methylation;

D O I：

10.5578/tt.10231

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported to play a major role in the genesis of lung cancer. DNA methylation, histone modifications, and RNA expression are epigenetic markers in assesment of early detection, prognosis and evaluation of treatment of lung cancer. In this rewiev we summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.

引用

页码：163 / 170

页数：8

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