SUBSTRATE-DEPENDENT ANGIOTENSIN-II FORMATION IN THE PERIPHERAL-CIRCULATION

被引：13

作者：

IDEISHI, M

SASAGURI, M

IKEDA, M

ARAKAWA, K

机构：

[1] Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka

来源：

LIFE SCIENCES | 1990年 / 46卷 / 05期

关键词：

D O I：

10.1016/0024-3205(90)90012-G

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

An alternative angiotensin II-forming system distinct from the vascular renin-angiotensin system was demonstrated using a rat hindlimb perfusion system and synthetic substrates. This pathway was resistant to captopril and aprotinin, but was highly sensitive to chymostatin. Moreover, angiotensin II formation was substrate-dependent, i.e. angiotensin II formation from tridecapeptide human renin substrate in the presence of captopril was more than twice that that from an equimolar amount of angiotensin I. Both pathways may play a role in regulating the peripheral circulation. © 1990.

引用

页码：335 / 341

页数：7

共 24 条

[1] ABILITY OF KALLIKREIN TO GENERATE ANGIOTENSIN-II-LIKE PRESSOR SUBSTANCE AND A PROPOSED KININ-TENSIN ENZYME-SYSTEM [J].