PROSTAGLANDIN BIOSYNTHESIS BY GUINEA-PIG SKELETAL-MUSCLE INVITRO AND THE EFFECT OF OESTRADIOL-17-BETA AND PROGESTERONE

被引：5

作者：

KERRY, PJ

机构：

[1] Department of Pharmacology, University of Edinburgh, Edinburgh, EH8 9JZ, George Square

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb07849.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of oestradiol and progesterone on prostaglandin biosynthesis by guinea‐pig skeletal muscle in vitro has been investigated. At high concentrations, oestradiol‐17β (100 μg/ml) and progesterone (500 μg/ml) increased prostaglandin E and prostaglandin F synthesis (measured by radioimmunoassay). It is suggested that these steroids are unlikely to be found in vivo at levels sufficient to influence prostaglandin synthesis by skeletal muscle in physiological and pathological situations. 1979 British Pharmacological Society

引用

页码：447 / 450

页数：4

共 10 条

[1]

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[2]

BODEL P, 1972, J LAB CLIN MED, V80, P373

[3] DEVELOPMENT OF ANTISERA TO PROSTAGLANDINS B2 AND F2ALPHA AND THEIR ANALYSIS USING SOLID-PHASE AND DOUBLE ANTIBODY RADIOIMMUNOASSAY METHODS [J].