IGG1 AND IGG2 ARE THE PREDOMINANT SUBCLASSES OF ANTIPHOSPHOLIPID ANTIBODY IN WOMEN WITH THE LUPUS ANTICOAGULANT

被引:17
作者
DOSTALJOHNSON, D
ROTE, NS
BRANCH, DW
机构
[1] UNIV SO MAINE,DEPT APPL MED SCI,PORTLAND,ME 04103
[2] UNIV UTAH,DEPT OBSTET & GYNECOL,SALT LAKE CITY,UT 84132
[3] MAINE MED CTR,DEPT OBSTET & GYNECOL,PORTLAND,ME 04102
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1990年 / 54卷 / 02期
关键词
D O I
10.1016/0090-1229(90)90092-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We studied the sera of 36 patients with lupus anticoagulant and IgG antibodies against both phosphatidylserine and cardiolipin. Most sera also had IgG antibodies against other phospholipids: 97% against phosphatidylinositol, 91% against phosphatidylglycerol, and 82% against phosphatidylethanolamine. IgG2 was the predominant subclass against cardiolipin and phosphatidylserine; 35 of 36 patients (98%) had IgG2 against both phospholipids. Most patients also had the IgG1 subclass; 32 of 36 (89%) against cardiolipin and 25 of 36 (69%) against phosphatidylserine. IgG3 and IgG4 subclasses were present at very low concentrations and in only a minority of the sera. The antibody response against phosphatidylserine was characterized by significantly less IgG1 than was the response against cardiolipin (P < 0.01), although the IgG2 responses against each phospholipid were not different. IgG subclasses were unrelated to any other aspect of the patients' history, including a history of thrombocytopenia or thrombosis, a positive antinuclear antibody test, or a diagnosis of systemic lupus erythematosus. © 1990.
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页码:309 / 319
页数:11
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