Aerobic Training: Effect on Liver Oxidative Stress

The aim of this study was to evaluate in an animal model the effect of aerobic training on hepatic oxidative status. Control (without exercise) Aerobic Training (EA) and Exercise Eventually (EE): 30 NMRI male mice were divided into 3 groups of 10 were used. Physical activity was conducted in an exercise wheel rotating at 50 rpm / 30 minutes / day / six weeks for the group with AD and 50 rpm / 30 minutes / once for EE. Albumin concentration was determined in blood, liver and the concentration of conjugated diene, malondialdehyde, reduced glutathione (GSH) was measured and histopathological study. The results show that animals made EE showed a marked increase in hepatic lipid peroxidation (LPO) compared with the control group and the EA. Regarding the antioxidant response, the concentration of GSH increased animals decreased in EA and EE and albumin was lower in animals who exercised. The GSH / LPO ratio was greater in animals EA, indicating a decrease in LPO in relation given by the GSH antioxidant response. No liver histopathological changes were observed. The results of this study show that despite an increase in hepatic lipid peroxidation occurs during exercise, this oxidation does not alter the histological structure of the organ and depending on the type of exercise, the body adapts by producing increased antioxidant defense based this training.