COVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD

被引：0

作者：

Chen, Hanfei ^{[1
,2
]}

Chen, Qiang ^{[1
,2
,3
]}

机构：

[1] Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa, Macau, Peoples R China

[2] Univ Macau, Fac Hlth Sci, Ctr Precis Med Res & Training, Taipa, Macau, Peoples R China

[3] Univ Macau, MOE Frontier Sci Ctr Precis Oncol, Taipa, Macau, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 11期

基金：

中国国家自然科学基金;

关键词：

COVID-19; SARS-CoV-2; MAFLD; NAFLD; Liver injury;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become an ongoing global health pandemic. Since 2019, the pandemic continues to cast a long shadow on all aspects of our lives, bringing huge health and economic burdens to all societies. With our in-depth understanding of COVID-19, from the initial respiratory tract to the later gastrointestinal tract and cardiovascular systems, the multiorgan involvement of this infectious disease has been discovered. Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named nonalcoholic fatty liver disease (NAFLD), is a major health issue closely related to metabolic dysfunctions, affecting a quarter of the world???s adult population. The association of COVID-19 with MAFLD has received increasing attention, as MAFLD is a potential risk factor for SARS-CoV-2 infection and severe COVID-19 symptoms. In this review, we provide an update on the interactions between COVID-19 and MAFLD and its underlying mechanisms.

引用

页码：4756 / 4767

页数：12

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