TAXOL PHOTOAFFINITY LABEL - 7-(PARA-AZIDOBENZOYL)TAXOL SYNTHESIS AND BIOLOGICAL EVALUATION

被引：28

作者：

GEORG, GI ^{[1
]}

HARRIMAN, GCB ^{[1
]}

HIMES, RH ^{[1
]}

MEJILLANO, MR ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期

关键词：

TAXOL; SYNTHESIS; BETA-LACTAMS; MICROTUBULE ASSEMBLY; PHOTOAFFINITY LABEL;

D O I：

10.1016/S0960-894X(00)80402-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6

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收藏

页码：735 / 738

页数：4

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