SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2-FUNCTIONALIZED-VINYL 1-BETA-METHYLCARBAPENEMS AND RELATED-COMPOUNDS

被引：9
作者：
IMUTA, M
ITANI, H
NISHI, K
ONA, H
UYEO, S
KIMURA, Y
机构：
[1] Shionogi Research Laboratories, Shionogi and Co., Ltd., Fukushima-ku, Osaka, 553, Sagisu
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)80925-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and antibacterial activity of the title compounds are described. Both 2-hydroxymethyl and 2-hydroxypropenyl carbapenems (3 and 14) served as the common key intermediates for the preparation of these compounds. The characteristic antibacterial activity was observed in the three types (A, B, and C) of derivatives prepared.
引用
收藏
页码：2199 / 2204
页数：6
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