ANALYSIS OF MECONIUM FOR COCAINE IN NEONATES

被引：33

作者：

BROWNE, SP

TEBBETT, IR

MOORE, CM

DUSICK, A

COVERT, R

YEE, GT

机构：

[1] UNIV ILLINOIS,DEPT PHARMACODYNAM,BOX 6998,CHICAGO,IL 60680

[2] UNIV CHICAGO,DEPT PEDIAT,CHICAGO,IL 60637

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 575卷 / 01期

关键词：

D O I：

10.1016/0378-4347(92)80518-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A solid-phase extraction method was developed for the extraction of first-day meconium samples from premature infants of cocaine-dependent mothers. Extracts were analysed by high-performance liquid chromatography and gas chromatography-mass spectrometry for cocaine and its metabolites. Control stools showed no drug. Meconium from cocaine-dependent mothers showed cocaine in the range 0.1-0.78-mu-g/g. Benzoylecgonine, ecgonine and ecgonine methyl ester were not present in the samples, which suggests that the metabolism of cocaine in the premature neonate is limited.

引用

页码：158 / 161

页数：4

共 5 条

[1]

CONE EJ, 1989, J FORENSIC SCI, V34, P32

[2]

HALSTEAD AC, 1988, CLIN BIOCHEM, V21, P49

[3] DRUG SCREENING OF MECONIUM IN INFANTS OF DRUG-DEPENDENT MOTHERS - AN ALTERNATIVE TO URINE TESTING [J].