A MOUSE-BRAIN CDNA ENCODES A NOVEL PROTEIN WITH THE PROTEIN-KINASE-C PHOSPHORYLATION SITE DOMAIN COMMON TO MARCKS

被引：49

作者：

UMEKAGE, T ^{[1
]}

KATO, K ^{[1
]}

机构：

[1] MRC,MOLEC GENET UNIT,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND

来源：

FEBS LETTERS | 1991年 / 286卷 / 1-2期

关键词：

MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE; PROTEIN KINASE-C; CALMODULIN;

D O I：

10.1016/0014-5793(91)80961-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a mouse brain cDNA clone encoding a protein of 200 amino acids (M(r) 20 165) with partial homology with MARCKS (myristoylated alanine-rich C-kinase substrate). Two regions show similarity with MARCKS, one is the kinase C phosphorylation site domain which is supposed to bind calmodulin, and the other is the region near to the N-terminus, including the consensus sequence of myristoylation. It has a similar amino acid composition to MARCKS, but the content of alanine is not as high. It is distributed throughout the mouse brain, but the pattern is not identical with that of MARCKS. Both proteins may be members of a new protein family involved in coupling the protein kinase C and calmodulin signal transduction systems.

引用

页码：147 / 151

页数：5

共 21 条

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