T-CELL RECEPTOR EXPRESSION AND ACTIVATION OF SYNOVIAL LYMPHOCYTE SUBSETS IN PATIENTS WITH RHEUMATOID-ARTHRITIS - PHENOTYPING OF MULTIPLE SYNOVIAL SITES

被引：84
作者：
REME, T
PORTIER, M
FRAYSSINOUX, F
COMBE, B
MIOSSEC, P
FAVIER, F
SANY, J
机构：
[1] HOP ST ELOI,CTR GUI DE CHAULIAC,SERV IMMUNORHUMATOL,F-34059 MONTPELLIER,FRANCE
[2] INSERM,SERV COMMUN CYTOMETRIE FLUX,F-34100 MONTPELLIER,FRANCE
来源：
ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 04期
关键词：
D O I：
10.1002/art.1780330404
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Two‐color flow cytometry analysis of peripheral blood and synovial lymphocytes from rheumatoid arthritis patients was performed using monoclonal antibodies directed against T cell subsets, T cell activation markers, and T cell receptors. The results showed an abnormally high percentage (>15%) of CD3+, CD4−, and CD8− T cells expressing a specific receptor containing a γ chain. Phenotypic analysis of lymphocytes infiltrating both knee joints of individual rheumatoid arthritis patients revealed very similar subset distribution and activation levels, despite strong differences in the clinical status between the 2 sites. Copyright © 1990 American College of Rheumatology
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页码：485 / 492
页数：8
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